Anbieter der Doktorarbeit |
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| Klinik / Institut / Zentrum | Innere Medizin - Hämatologie, Onkologie u. Rheumatologie |
| Doktorvater / -mutter | Prof. Müller-Tidow |
| Ansprechpartner | Dr. med. Khatamzas |
| Kontakt (E-Mail-Adresse) | elham.khatamzas@med.uni-heidelberg.de |
Beschreibung der Arbeit |
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| Art der Arbeit |
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| Thema der Promotion | Generation of aspergillus-specific NK-CAR Cells for treatment of invasive fungal infections |
| Voraussichtliche Dauer (in Monaten) | 3 |
| davon in Vollzeit (in Monaten) | 10 |
| Startzeitpunkt | |
| Methoden | CAR-NK cell generation and characterisation including survival and proliferation assays, cytokine detection, multicolor flow cytometry for immunophenotyping. Genome editing using CRISPR/CAS; Lentiviral and retroviral transduction |
| Zielsetzung | Chimeric antigen receptor (CAR)-NK cell therapy is a novel promising immunotherapeutic strategy for the treatment of various malignancies as well as non-malignant conditions. Invasive fungal infections are a major cause of morbidity and mortality in immunosuppressed patients. Targeted NK cell based antifungal therapy alongside conventional antifungals has the potential to improve treatment outcomes. Preliminary animal studies suggest promising potential using co-receptors such as dectin-1 that target specifically fungal cell wall of aspergillus, candida and zygomycetes. We plan to engineer CAR-NK cells with membrane bound IL15 and Dectin-1 and test their antifungal activity in vitro assays of A. fumigatus. |
Rahmenbedingungen |
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| Strukturierte Betreuung | Seminars, lab meetings, journal clubs, retreats and conferences |
| Anforderungen | We are looking for a highly motivated MD student with a strong interest in molecular cell biology and novel immunotherapeutic strategies |
| Finanzielle Unterstützung | Application for a doctoral scholarship is supported |
| Autorenschaft | Publications are planned and authorship definitely possible |
| Anmerkungen | |
| Flyer | |
