Functional genomics of the human endothelial nitric oxide synthase (NOS3) gene

Anbieter der Doktorarbeit

Beschreibung der Arbeit

culture of human endothelial cells and application of shear stress; full range of state-of-the-art molecular, cellular and biochemistry techniques; working with bulk/single cell-RNA-sequencing as well as ChIP-sequencing data

The proposed project (cf. flyer) will (alternatively) focus on I. the role of chromatin dynamics and DNA-transcription factor interaction in the control of NOS3 expression in human primary endothelial cells or on II. the characterization of the extracellular matrix synthesizing and remodeling capacity of these cells in relation to their genotype

Rahmenbedingungen

The successful candidate will be integrated into the MEDISS program; regular working group meetings; additional mentoring; participation in a national or international conference is planned.

One semester off is necessary to successfully complete the experiments in 12 month; strong interest in molecular and cell biology as well as cutting edge cardiovascular research.

The student can be financially supported as a certified student assistant (up to 85 hours per month).

Co-authorship on at least one publication is planned.

This project does not include animal experiments. For further details see attached flyer.