Peripheral and Autonomic Nerve Function Following Bariatric Surgery: A Clinical Evaluation

Anbieter der Doktorarbeit

Beschreibung der Arbeit

The CHARMED study is a prospective clinical cohort study enrolling participants undergoing either the Optimed lifestyle intervention program or bariatric surgery. All participants undergo a comprehensive baseline assessment prior to intervention and are subsequently re-evaluated at four follow-up visits over a two-year period. Clinical characterization comprises, but is not limited to: • Quantitative Sensory Testing (QST) for the assessment of somatosensory function • Nerve Conduction Studies (NCS) to evaluate large fibre integrity • Heart Rate Variability (HRV) as an indicator of autonomic nervous system function • Extensive metabolic, clinical, and anthropometric profiling

Obesity and (pre-)diabetes are associated with an increased prevalence of peripheral and autonomic neuropathies. Bariatric surgery often results in substantial improvements in glycemic control and metabolic parameters; however, its effects on peripheral and autonomic nerve functions are less well understood. Objectives • To evaluate pre- and postoperative changes in Quantitative Sensory Testing (QST), Nerve Conduction Studies (NCS), and Heart Rate Variability (HRV) • To correlate these changes with metabolic improvements, including HbA1c, body weight, lipid profile, and liver function status • To investigate differences between peripheral and autonomic nerve function

Rahmenbedingungen

You will receive structured methodological training, participate in weekly departmental seminars and professional development sessions, and have the opportunity to present your results at national and international conferences.

Freisemester

HiWi-Job possible

Authorship in top journals envisioned.

More information: Zoltan.Kender@med.uni-heidelberg.de. We are looking forward to you joining our team!