Hydrodynamic behavior of Plasmodium falciparum infected red blood cells in flow.

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Klinik / Institut / Zentrum Infektiologie - Parasitologie
Doktorvater / -mutter Prof. Dr. Michael Lanzer
Ansprechpartner Prof. Dr. Michael Lanzer
Kontakt (E-Mail-Adresse) michael.lanzer@med.uni-heidelberg.de

Beschreibung der Arbeit

Art der Arbeit
  • experimentell
Thema der Promotion Hydrodynamic behavior of Plasmodium falciparum infected red blood cells in flow.
Voraussichtliche Dauer (in Monaten) 9-12
davon in Vollzeit (in Monaten) 9
Startzeitpunkt as soon as possible
Methoden

The project involves tissue culture of P. falciparum, flow chamber experiments, high speed microscopy and data modelling. The project will be jointly orchestrated by the Institutes for Physical Chemistry (Prof. Tanaka) and Theoretical Physics (Prof. Schwarz) and the Department of Parasitology (Prof. Lanzer).

Zielsetzung

The pathology of falciparum malaria is associated with the cytoadhesive properties of erythrocytes infected with the protozoan parasite Plasmodium falciparum. Parasitized erythrocytes display a broad spectrum of adhesive interactions and can bind to microvascular endothelial cells, matrix proteoglycans, and uninfected red blood cells. The latter phenomenon is termed rosetting. While firm and dynamic cytoadhesion to microvascular endothelial cells in flow is understood in ever greater detail, very little is known about the behavior of rosettes under hydrodynamic conditions. The objective of the MD project is to obtain quantitative information regarding their rotational and translational speed. In addition, it is planned to study how rosettes affect the hydrodynamic behavior of uninfected erythrocytes and how rosettes disturb the blood flow and contribute to capillary occlusion.

Rahmenbedingungen

Strukturierte Betreuung

Departmental Seminar (weekly), Group meeting (weekly), Journal Club (weekly) etc.

Anforderungen
Finanzielle Unterstützung

HiWi contract

Autorenschaft

co-authorship in planning

Anmerkungen
Flyer

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